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Palmitoyl Tripeptide-1(Pal-GHK)

时间:2019-03-04 10:15:54 阅读数:0

棕榈酰三肽-1.png

 


Structural Representation of Palmitoyl Tripeptide-1(Pal-GHK)


Chemical Properties

Product Name

Palmitoyl Tripeptide-1
Chinese Name棕榈酰三肽-1  |   棕榈酰寡肽   |   基肽 3000
CAS NO147732-56-7MFC30H54N6O5
SequencePal-Gly-Gln-Pro-ArgMolecular Weight578.787
Package100g,1KgAppearance: White Freeze-dried PowerStorage: 2~8℃
Description

Anti-wrinkle and anti-aging, improve skin quality, facial and phtsical care, facial, neck and hand care products.

 It can be added to skin care prodicts, such as lotion, morning cream, eye essence, etc.

ApplicationCosmetic raw materials

Advantage of Readline

- Purity(HPLC):99%Content: 85%

- Acetic Acid: 8%Moisture:  8%

- 20% below market price

- 10kg per month


Efficacy and Mechanism of Action

Palmitoyl tripeptide-1, also known as pal-GHK and palmitoyl oligopeptide (sequence: Pal-Gly-His-Lys), is a messenger peptide for collagen renewal. Retinoic acid has the same activity as retinoic acid and does not cause stimulation. Stimulate collagen and glycosaminoglycan synthesis, enhance the epidermis, reduce wrinkles. It is suggested that the peptide acts on TGF to stimulate fibrillary formation. It is used in cosmetics, wrinkle-resistant skin care and cosmetic products.


Experimental data and research reports

In a study of 15 women, the use of cream containing palmitoyl Tripeptide-1 twice a day for four weeks resulted in significant statistical decreases in wrinkle length, depth and skin roughness. In another study, vector and palmitoyl Tripeptide-1 were applied to the skin of 23 healthy female volunteers for four weeks, recording a small but statistically significant increase in skin thickness (about 4% compared with a single carrier).

The combination of pal-GHK tripeptide and pal-GQPR tetrapeptide is sold under the trade name Matrixyl TM 3000 as a wrinkle-resistant compound. In a blind, randomized clinical trial, a total of 28 volunteers applied cream two times a day, including half of the active compound. One forearm and one placebo cream to the other half of the face and other forearms proved wrinkle resistance, reduced wrinkle depth, volume and density, skin roughness and complexity, and reduced the area of deep wrinkles, as well as increased skin color.


Clinical application cases

Avon, L'Oréal, Chanel, Estee Lauder, United Laboratories

Sederma (France)